منابع مشابه
Transcriptional Fidelity and Proofreading by RNA Polymerase II
We have addressed whether the intrinsic 3'-->5' nuclease activity of human RNA polymerase II (pol II) can proofread during transcription in vitro. In the presence of SII, a protein that stimulates the nuclease activity, pol II quantitatively removed misincorporated nucleotides from the nascent transcript during rapid chain extension. The basis of discrimination between the correct and incorrect...
متن کاملIi . the Search for Fidelity in Modern Architectural Visualization
ii ACKNOWLEDGEMENTS This thesis would never have been completed without the instruction and help of my thesis committee. Here I would like to appreciate sincerely to all those who supported me during my whole thesis period. I would particularly like to thank Professor Glenn Hill for his patient direction, support and training. His deep insight and thoughtful suggestions to my thesis guide my di...
متن کاملSub- and super-fidelity as bounds for quantum fidelity
We derive several bounds on fidelity between quantum states. In particular we show that fidelity is bounded from above by a simple to compute quantity we call super–fidelity. It is analogous to another quantity called sub–fidelity. For any two states of a two– dimensional quantum system (N = 2) all three quantities coincide. We demonstrate that sub– and super–fidelity are concave functions. We ...
متن کاملLoop II of DNA polymerase beta is important for polymerization activity and fidelity
The accurate replication and transmission of genetic information is critical in the life of an organism. During its entire lifespan, the genetic information is constantly under attack from endogenous and exogenous sources of damage. To ensure that the content of its genetic information is faithfully preserved for synthesis and transmission, eukaryotic cells have developed a complex system of ge...
متن کاملStructural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA.
We show that RNA polymerase (Pol) II prevents erroneous transcription in vitro with different strategies that depend on the type of DNARNA base mismatch. Certain mismatches are efficiently formed but impair RNA extension. Other mismatches allow for RNA extension but are inefficiently formed and efficiently proofread by RNA cleavage. X-ray analysis reveals that a TU mismatch impairs RNA extensio...
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ژورنال
عنوان ژورنال: The Iowa Review
سال: 2015
ISSN: 0021-065X,2330-0361
DOI: 10.17077/0021-065x.7558